Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015780 | 1.00 | KMT2A (0.42) | KMT2ASMN1; SMN2MEN1EPHX2EPHX1 | |
| SCHEMBL5015764 | 0.91 | TRPV1 (0.46) | KMT2ASMN1; SMN2MEN1EPHX2EPHX1 | |
| SCHEMBL16175718 | 0.91 | TRPM8 (0.42) | KMT2ASMN1; SMN2MEN1EPHX2TP53 | |
| SCHEMBL5012824 | 0.91 | GAA (0.45) | KMT2ASMN1; SMN2MEN1EPHX2GAA | |
| SCHEMBL5012816 | 0.89 | FPR1 (0.40) | KMT2AEPHX2TRPM8 | |
| SCHEMBL5061182 | 0.89 | KDM4E (0.43) | KMT2ASMN1; SMN2MEN1TP53KDM4E | |
| SCHEMBL5012899 | 0.88 | KMT2A (0.46) | KMT2ASMN1; SMN2MEN1MAPTALDH1A1 | |
| SCHEMBL5129802 | 0.87 | TRPM8 (0.52) | EPHX2TRPM8 | |
| SCHEMBL5124312 | 0.87 | TRPM8 (0.52) | EPHX2TRPM8 | |
| SCHEMBL5012813 | 0.86 | MAPT (0.42) | KMT2ASMN1; SMN2EPHX2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |