Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136184 | 0.82 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3ALDH1A1TSHR | |
| SCHEMBL5013383 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3DPP4ALDH1A1 | |
| SCHEMBL4986376 | 0.81 | DPP4 (0.47) | DPP4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30539494 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3DPP4ALDH1A1 | |
| SCHEMBL5012150 | 0.81 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL5013663 | 0.79 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3DPP4ALDH1A1 | |
| SCHEMBL19469843 | 0.79 | NPC1 (0.47) | DPP4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30415207 | 0.79 | NPC1 (0.47) | DPP4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11011803 | 0.79 | CYP4F2 (0.41) | SLC6A2SLC6A4SLC6A3ALDH1A1KDM4E | |
| SCHEMBL21385911 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975091-B2 | Pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2021-04-13 | — | — | US | disclosed |
| EP-3150581-B1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2020-04-15 | — | — | EP | disclosed |
| US-20200055868-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2020-02-20 | — | — | US | disclosed |
| US-10421762-B2 | Pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2019-09-24 | — | — | US | disclosed |
| US-20180327418-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2018-11-15 | — | — | US | disclosed |
| US-10059720-B2 | Pyridine derivative | ASTELLAS PHARMA INC. (JP) | 2018-08-28 | — | — | US | disclosed |
| US-20170190715-A1 | PYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2017-07-06 | — | — | US | disclosed |
| EP-3150581-A1 | PYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055868-A1 | PYRIDINE DERIVATIVE | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
| US-10975091-B2 | Pyridine derivative | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
| US-20180327418-A1 | PYRIDINE DERIVATIVE | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | SLC6A2 3703/4885SLC6A4 2705/4885SLC6A3 1721/4885 |
| US-10059720-B2 | Pyridine derivative | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
| US-10421762-B2 | Pyridine derivative | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
| US-20170190715-A1 | PYRIDINE DERIVATIVE | LAP3, PREP, DNPEP | SLC6A2 409/4885SLC6A4 765/4885SLC6A3 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.