Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16102104 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL10008577 | 0.79 | KMT2A (0.61) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL10008580 | 0.79 | KMT2A (0.61) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL10009481 | 0.76 | MMP1 (0.57) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL5017650 | 0.76 | NPC1 (0.55) | SMN1; SMN2KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL10009478 | 0.76 | MMP1 (0.57) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL5015389 | 0.73 | DEGS1 (0.48) | KMT2ADEGS1RAB9ANPC1ALDH1A1 | |
| SCHEMBL10299114 | 0.71 | EGFR (0.62) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL10010523 | 0.71 | EGFR (0.62) | SMN1; SMN2KMT2ALMNAMAPTMITF | |
| SCHEMBL10010527 | 0.71 | EGFR (0.62) | SMN1; SMN2KMT2ALMNAMAPTMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | SMN1; SMN2 1564/4885KMT2A 3504/4885LMNA 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.