Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 5/20 | 0.51 |
| ▸ | F12 | P00748 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015389 | 0.78 | DEGS1 (0.48) | NPC1RAB9AADORA1ADORA3ADORA2A | |
| SCHEMBL31060745 | 0.78 | NPC1 (0.58) | NPC1RAB9ACYP1A2CYP3A4GAA | |
| SCHEMBL6307534 | 0.78 | NPC1 (0.58) | NPC1RAB9ACYP1A2CYP3A4GAA | |
| SCHEMBL4405832 | 0.77 | CYP1A2 (0.50) | NPC1RAB9ACYP1A2CYP3A4GAA | |
| SCHEMBL5014078 | 0.76 | SMN1; SMN2 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2LMNA | |
| SCHEMBL5015439 | 0.76 | TSHR (0.56) | NPC1RAB9ACYP1A2GAAADORA3 | |
| SCHEMBL5013515 | 0.76 | CCNE1 (0.50) | RAB9AADORA1ADORA3KMT2AMEN1 | |
| SCHEMBL31412961 | 0.76 | ROCK2 (0.47) | CYP1A2GAAADORA1ADORA3AURKA | |
| SCHEMBL678202 | 0.76 | LMNA (0.55) | JAK2CYP1A2CYP3A4GAACYP2C19 | |
| SCHEMBL8720225 | 0.75 | CDK2 (0.59) | NPC1RAB9AJAK2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | NPC1 795/4885RAB9A 1142/4885JAK2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.