Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 6/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015439 | 0.86 | TSHR (0.56) | ALDH1A1MEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL5013515 | 0.81 | CCNE1 (0.50) | CDK2CCNE1ALDH1A1MEN1KMT2A | |
| SCHEMBL5017650 | 0.78 | NPC1 (0.55) | CDK2ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL13731141 | 0.77 | DEGS1 (0.54) | DEGS1EPHX2CDK2CCNA2CCNE1 | |
| SCHEMBL5014078 | 0.73 | SMN1; SMN2 (0.57) | DEGS1ALDH1A1KMT2AHDAC3HDAC4 | |
| SCHEMBL31412961 | 0.72 | ROCK2 (0.47) | CDK2CCNA2ADORA3ADORA1POLB | |
| SCHEMBL16061776 | 0.71 | EPHX2 (0.50) | DEGS1EPHX2CDK2CCNE1CDK5 | |
| SCHEMBL2492016 | 0.71 | EPHX2 (0.58) | DEGS1EPHX2CDK2CCNE1CDK5 | |
| SCHEMBL13934555 | 0.71 | EPHX2 (0.53) | DEGS1EPHX2CDK2CCNE1CDK5 | |
| SCHEMBL6774592 | 0.70 | MAPT (0.51) | ALDH1A1MAPK1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | DEGS1 4692/4885EPHX2 3963/4885CDK2 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.