Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 4/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15679080 | 0.85 | ELANE (0.55) | PARP10MAPTALDH1A1POLBELANE | |
| SCHEMBL23493150 | 0.85 | ELANE (0.55) | PARP10MAPTALDH1A1POLBELANE | |
| Hydrochloric Acid SCHEMBL30184762 | 0.83 | ELANE (0.53) | PARP10MAPTALDH1A1POLBELANE | |
| SCHEMBL19441077 | 0.83 | MGLL (0.47) | PARP15PARP10PARP2MGLLMAPT | |
| SCHEMBL28035766 | 0.83 | ELANE (0.43) | PARP10CA1CA2CA9ELANE | |
| SCHEMBL22329031 | 0.82 | PARP15 (0.41) | PARP15PARP10PARP2MGLLMAPT | |
| SCHEMBL4441563 | 0.81 | MGLL (0.55) | MGLL | |
| SCHEMBL10033505 | 0.80 | MGLL (0.51) | PARP15PARP10PARP2MGLLMAPT | |
| SCHEMBL15679089 | 0.78 | ELANE (0.48) | PARP10MAPTCA1CA2CA9 | |
| SCHEMBL5058438 | 0.78 | LMNA (0.55) | MAPTALDH1A1ELANEGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104995207-B | β integrin-G protein α subunit binding interaction inhibitors | 伊利诺伊州大学理事会 | 2018-08-07 | — | — | CN | disclosed |
| CN-104379146-B | Inhibit the composition and method of varial polymerases | 拜奥克里斯特制药公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-106573073-A | FAP-activated therapeutics and uses related thereto | 塔夫茨大学信托人 | 2017-04-19 | — | — | CN | disclosed |
| CN-103265495-B | Multicyclic amino acid derivatives and using method thereof | 莱西肯医药有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-104379146-A | Compositions and methods for inhibiting viral polymerase | BIOCRYST PHARM INC | 2015-02-25 | — | — | CN | disclosed |
| CN-103265495-A | Multicyclic amino acid derivatives and methods of their use | LEXICON GENETICS INC | 2013-08-28 | — | — | CN | disclosed |
| CN-101351451-B | Polycyclic amino acid derivatives and methods of use thereof | LEXICON PHARMACEUTICALS INC | 2013-02-20 | — | — | CN | disclosed |
| US-20130022620-A1 | ASSAYS AND METHODS PERTAINING TO PRE-AMYLOID INTERMEDIATES | NATIONAL INSTITUTES OF HEALTH | 2013-01-24 | — | — | US | disclosed |
| CN-102753168-A | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease | LEXICON PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | disclosed |
| CN-102711749-A | Tryptophan hydroxylase inhibitors for the treatment of cancer | LEXICON PHARMACEUTICALS INC | 2012-10-03 | — | — | CN | disclosed |
| CN-101969952-A | Compositions comprising tryptophan hydroxylase inhibitors | LEXICON PHARMACEUTICALS INC | 2011-02-09 | — | — | CN | disclosed |
| CN-101815534-A | methods and compositions for treating pulmonary hypertension and related diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-08-25 | — | — | CN | disclosed |
| CN-101801385-A | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein | LEXICON PHARMACEUTICALS INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101784269-A | methods of treating serotonin-mediated diseases and disorders | LEXICON PHARMACEUTICALS INC | 2010-07-21 | — | — | CN | disclosed |
| CN-101351451-A | Polycyclic amino acid derivatives and methods of use thereof | LEXICON GENETICS INC (US) | 2009-01-21 | — | — | CN | disclosed |
| CN-101287485-A | Anti-angiogenic compounds | IRELAND KALVEKS TECHNOLOGY CO (IE) | 2008-10-15 | — | — | CN | disclosed |
| WO-2008031016-A2 | HETEROCYCLIC LIGANDS FOR INTEGRIN IMAGING AND THERAPY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-03-13 | — | — | WO | disclosed |