Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822989 | 0.84 | ALDH1A1 (0.59) | POLBGAAGFERALDH1A1CYP1A2 | |
| SCHEMBL30078376 | 0.84 | ALDH1A1 (0.59) | POLBGAAGFERALDH1A1CYP1A2 | |
| SCHEMBL6572888 | 0.82 | ALDH1A1 (0.61) | POLBGAAGFERALDH1A1CYP1A2 | |
| SCHEMBL2683313 | 0.82 | CYP1A2 (0.37) | ALDH1A1CYP1A2MAPK1GABRA1GABRB2 | |
| SCHEMBL5014685 | 0.81 | LMNA (0.38) | POLBGAAGFERALOX15GABRA1 | |
| SCHEMBL5015066 | 0.79 | ALDH1A1 (0.34) | ALDH1A1CYP1A2MAPK1NOS3NOS1 | |
| SCHEMBL5022865 | 0.77 | MAPK1 (0.34) | POLBALDH1A1CYP1A2ALOX15MAPK1 | |
| SCHEMBL25555727 | 0.77 | POLB (0.61) | POLBGAAGFERALDH1A1CYP1A2 | |
| SCHEMBL15927422 | 0.77 | POLB (0.45) | POLBGAAGFERALDH1A1CYP1A2 | |
| SCHEMBL5022863 | 0.76 | CYP1A2 (0.33) | CYP1A2MAPK1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |