Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 3/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1086828 | 0.77 | ALDH1A1 (0.41) | F2PLAUELANECTRB1MEN1 | |
| SCHEMBL5011747 | 0.73 | KCNK3 (0.40) | LMNAELANEKMT2AALDH1A1CYP1A2 | |
| SCHEMBL5011835 | 0.72 | CYP1A2 (0.43) | LMNAMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL1086148 | 0.68 | ALDH1A1 (0.40) | MAPTMEN1KMT2AALDH1A1KCNJ1 | |
| SCHEMBL1086864 | 0.66 | KCNJ1 (0.39) | LMNAHTTMAPTKMT2AALDH1A1 | |
| SCHEMBL1086417 | 0.65 | ALDH1A1 (0.42) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL1086535 | 0.65 | KCNJ1 (0.47) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL1086474 | 0.64 | ALDH1A1 (0.44) | LMNAHTTMAPTMEN1KMT2A | |
| SCHEMBL5011879 | 0.64 | KMT2A (0.38) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1086473 | 0.63 | MAPK1 (0.48) | LMNATDP1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |