Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | CCR9 | P51686 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011835 | 0.91 | CYP1A2 (0.43) | KCNK3HPGDLMNAALDH1A1CYP2C9 | |
| SCHEMBL5016329 | 0.89 | CHRM2 (0.43) | HPGDLMNAKMT2AALDH1A1OPRK1 | |
| SCHEMBL5011651 | 0.78 | CHRM2 (0.44) | LMNAKMT2AALDH1A1 | |
| SCHEMBL1086619 | 0.74 | ALDH1A1 (0.46) | HPGDKMT2AALDH1A1GABRDGABRA1 | |
| SCHEMBL5011879 | 0.73 | KMT2A (0.38) | HPGDLMNAKMT2AALDH1A1OPRM1 | |
| SCHEMBL5015148 | 0.73 | LMNA (0.45) | LMNAKMT2AALDH1A1ELANECYP2C9 | |
| SCHEMBL5015165 | 0.70 | ATM (0.47) | HPGDLMNAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL5011708 | 0.70 | CYP1A2 (0.45) | HPGDLMNAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL5011764 | 0.67 | HTT (0.44) | HPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL1086170 | 0.65 | EPHX2 (0.46) | HPGDALDH1A1CYP2C9CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |