Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.45 |
| ▸ | KDM6B | O15054 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29571308 | 0.89 | TDP1 (0.68) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL258230 | 0.89 | TDP1 (0.68) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| Hydrochloric Acid SCHEMBL1536025 | 0.87 | TDP1 (0.66) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL9504678 | 0.87 | TDP1 (0.66) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| Trifluoroacetic Acid SCHEMBL30368991 | 0.86 | KDM4C (0.49) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL8687513 | 0.78 | TDP1 (0.54) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| Trifluoroacetic Acid SCHEMBL3973104 | 0.76 | LOXL2 (0.46) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| Toluic Acid SCHEMBL4746481 | 0.74 | ALDH1A1 (0.52) | TDP1KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL30281300 | 0.74 | KDM4C (0.59) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL115797 | 0.74 | KDM4C (0.59) | TDP1SIRT3KDM4CKDM6BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |