Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016249 | 0.88 | SMN1; SMN2 (0.45) | KDM4EMAPK1DRD2DRD3LMNA | |
| SCHEMBL2093990 | 0.84 | ADORA2A (0.35) | KDM4EDRD2DRD3ALDH1A1MAPT | |
| SCHEMBL27644609 | 0.81 | DRD2 (0.48) | KDM4EMAPK1DRD2DRD3LMNA | |
| SCHEMBL5013440 | 0.81 | TP53 (0.36) | KDM4ELMNAALDH1A1MAPTHTR1A | |
| SCHEMBL2091406 | 0.79 | ACACB (0.34) | MAPTHTR1A | |
| SCHEMBL2093999 | 0.72 | ADORA2A (0.35) | KDM4EDRD2DRD3LMNAALDH1A1 | |
| SCHEMBL5546069 | 0.70 | KDM4E (0.49) | KDM4EMAPK1DRD2DRD3LMNA | |
| SCHEMBL2095879 | 0.67 | — | — | |
| SCHEMBL5016235 | 0.67 | RAB9A (0.46) | KDM4EDRD2DRD3LMNAALDH1A1 | |
| SCHEMBL2091415 | 0.67 | ACACB (0.34) | LMNAKMT2AMEN1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |