Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.74 |
| ▸ | AURKA | O14965 | 4/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.66 |
| ▸ | EGFR | P00533 | 8/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652035 | 0.90 | AURKA (0.68) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5651730 | 0.90 | AURKB (0.81) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5023471 | 0.90 | KDR (0.74) | KDRAURKAAURKBEGFRMAPK14 | |
| Hydrochloric Acid SCHEMBL2463942 | 0.89 | AURKB (0.80) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5023544 | 0.88 | AURKA (0.67) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5023489 | 0.87 | AURKA (0.78) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5650776 | 0.87 | AURKA (0.71) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5091097 | 0.86 | AURKA (0.70) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5649152 | 0.85 | AURKA (0.69) | KDRAURKAAURKBEGFRMAPK14 | |
| SCHEMBL5653702 | 0.84 | AURKA (0.71) | KDRAURKAAURKBEGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575966-B1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | disclosed |
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| US-20060058325-A1 | Therapeutic quniazoline derivatives | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1575966-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058782-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058325-A1 | Therapeutic quniazoline derivatives | NQO2, ABL1, CYP3A7 | KDR 3166/4885AURKA 376/4885AURKB 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.