Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | STAT3 | P40763 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354766 | 0.85 | RAB9A (0.65) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL29151264 | 0.85 | RAB9A (0.65) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL30354939 | 0.85 | RAB9A (0.65) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL5025455 | 0.85 | RAB9A (0.65) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL5651517 | 0.85 | STAT3 (0.61) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL2664545 | 0.84 | NPC1 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL30354968 | 0.84 | NPC1 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL3165548 | 0.83 | RAB9A (0.77) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL30354767 | 0.82 | PTGS1 (0.67) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL29151324 | 0.82 | PTGS1 (0.67) | ALDH1A1MAPTHTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113061098-B | Amide compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |
| CN-113061098-A | Amide compound and derivative thereof, preparation method, pharmaceutical composition and application | 中国药科大学 | 2021-07-02 | — | — | CN | disclosed |
| EP-1575966-B1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | disclosed |
| US-20060058325-A1 | Therapeutic quniazoline derivatives | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1575966-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058782-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058325-A1 | Therapeutic quniazoline derivatives | NQO2, ABL1, CYP3A7 | ALDH1A1 1955/4885MAPT 751/4885HTT 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.