Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.56 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016607 | 0.85 | ALDH1A1 (0.65) | STAT3KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL2063757 | 0.83 | KMT2A (0.60) | ALOX5KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1942220 | 0.82 | KCNQ3 (0.55) | STAT3KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL5649097 | 0.81 | KCNQ3 (0.61) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL13802456 | 0.80 | MEN1 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1ALOX5 | |
| SCHEMBL28581285 | 0.79 | MAPT (0.53) | STAT3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL29886205 | 0.79 | MAPT (0.53) | STAT3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL13802453 | 0.78 | MEN1 (0.81) | ALOX5KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL399870 | 0.76 | MEN1 (0.68) | ALOX5KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL12834030 | 0.76 | MEN1 (0.64) | STAT3ALOX5KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |