Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4300398 | 0.83 | TSHR (0.45) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL1628532 | 0.78 | NPSR1 (0.42) | TSHRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3165753 | 0.78 | TRPV4 (0.39) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL29907686 | 0.78 | TRPV4 (0.39) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL20732874 | 0.78 | ALDH1A1 (0.39) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL10933249 | 0.78 | ALDH1A1 (0.41) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL13979471 | 0.78 | ALDH1A1 (0.41) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL29330206 | 0.78 | ALDH1A1 (0.41) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL29330383 | 0.76 | ALDH1A1 (0.37) | TSHRALDH1A1ALOX15HSD17B10MAPT | |
| SCHEMBL11255247 | 0.75 | ALDH1A1 (0.40) | TSHRALDH1A1ALOX15HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |