Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165753 | 1.00 | TRPV4 (0.39) | TRPV4ARALDH1A1ALOX15TSHR | |
| SCHEMBL4300509 | 0.84 | TRPV4 (0.52) | TRPV4ALDH1A1ALOX15TSHRHSD17B10 | |
| SCHEMBL5017012 | 0.78 | TSHR (0.45) | ALDH1A1ALOX15TSHRHSD17B10MAPT | |
| SCHEMBL931882 | 0.77 | TRPV4 (0.34) | TRPV4ARALDH1A1MAPTKDM4E | |
| SCHEMBL29331393 | 0.77 | MAPT (0.36) | TRPV4ALDH1A1ALOX15TSHRMAPT | |
| SCHEMBL29330206 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRHSD17B10MAPT | |
| SCHEMBL20732874 | 0.76 | ALDH1A1 (0.39) | ALDH1A1ALOX15TSHRHSD17B10MAPT | |
| SCHEMBL13979471 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRHSD17B10MAPT | |
| SCHEMBL10933249 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRHSD17B10MAPT | |
| SCHEMBL29330383 | 0.74 | ALDH1A1 (0.37) | ALDH1A1ALOX15TSHRHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |