Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.39 |
| ▸ | CTSS | P25774 | 12/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | CTSB | P07858 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018049 | 0.83 | CTSK (0.43) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5017270 | 0.82 | CTSK (0.42) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5024453 | 0.81 | CTSK (0.56) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5022259 | 0.81 | CTSK (0.48) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5017183 | 0.80 | CTSK (0.55) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5024475 | 0.77 | CTSK (0.54) | CTSKKCNH2CTSSCTSB | |
| SCHEMBL4444120 | 0.70 | CTSK (0.74) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5798433 | 0.69 | CTSK (0.66) | CTSKKCNH2CTSS | |
| SCHEMBL4593268 | 0.69 | CYP11B1 (0.38) | CTSKCTSS | |
| SCHEMBL4448466 | 0.67 | CTSK (0.71) | CTSKKCNH2CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758870-B1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | ORGANON NV (NL) | 2008-08-13 | — | — | EP | claimed |