Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 11/20 | 0.34 |
| ▸ | CTSS | P25774 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5022259 | 0.74 | CTSK (0.48) | CTSKCTSS | |
| SCHEMBL5024453 | 0.71 | CTSK (0.56) | CTSKCTSS | |
| SCHEMBL5018049 | 0.70 | CTSK (0.43) | CTSKCTSS | |
| SCHEMBL5017270 | 0.69 | CTSK (0.42) | CTSKCTSS | |
| SCHEMBL5024475 | 0.69 | CTSK (0.54) | CTSKCTSS | |
| SCHEMBL5017262 | 0.69 | CTSK (0.39) | CTSKCTSS | |
| SCHEMBL5017183 | 0.67 | CTSK (0.55) | CTSKCTSS | |
| SCHEMBL3873554 | 0.66 | CTSK (0.67) | CTSKCTSS | |
| SCHEMBL4970801 | 0.65 | CTSS (0.33) | CTSSSMN1; SMN2 | |
| SCHEMBL11685984 | 0.65 | ALDH1A1 (0.34) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928842-A1 | 4-PHENYL-6-SUBSTITUTED-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. Organon (NL) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007039470-A1 | 4-PHENYL-6-SUBSTITUTED-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2007-04-12 | — | — | WO | disclosed |