Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.60 |
| ▸ | NPC1 | O15118 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18711482 | 0.78 | NPC1 (0.74) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13153255 | 0.78 | RAB9A (0.65) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL18701805 | 0.75 | NPC1 (1.00) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL6125228 | 0.73 | RAB9A (0.70) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL10219244 | 0.72 | NPC1 (0.72) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL28142588 | 0.72 | RAB9A (0.72) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL2072963 | 0.72 | RAB9A (0.71) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL2202283 | 0.72 | RAB9A (0.69) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8526236 | 0.71 | RAB9A (0.73) | RAB9ANPC1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13902467 | 0.70 | RAB9A (0.67) | RAB9ANPC1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871372-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | Neuromed Pharmaceuticals, Ltd. (CA) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105670-A1 | COMBINATION THERAPY COMPRISING AN N-TYPE CALCIUM CHANNEL BLOCKER FOR THE ALLEVIATION OF PAIN | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-10-12 | — | — | WO | disclosed |