Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.72 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.72 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10400126 | 0.88 | PDK1 (0.65) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL5103222 | 0.87 | PDK1 (0.71) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL30093275 | 0.87 | PDK1 (0.71) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL10041286 | 0.81 | PDK1 (0.71) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL95284 | 0.78 | PDK1 (0.68) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL6857920 | 0.78 | KMT2A (0.73) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL11332310 | 0.78 | KMT2A (0.73) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL16077783 | 0.76 | PDK1 (0.64) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL1745798 | 0.76 | KMT2A (0.71) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL175272 | 0.76 | MEN1 (0.71) | PDK1PDK2PDK3PDK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456293-B2 | Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use | SK HOLDING CO., LTD (KR) | 2008-11-25 | — | — | US | disclosed |
| EP-1869004-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES AND LIPID DISORDERS, THEIR PREPARATION AND USE | SK Holdings Co., Ltd. (KR) | 2007-12-26 | — | — | EP | disclosed |
| US-20060281802-A1 | Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2006-12-14 | — | — | US | disclosed |
| WO-2006104349-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES AND LIPID DISORDERS, THEIR PREPARATION AND USE | SK HOLDINGS CO., LTD. (KR) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281802-A1 | Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use | SLC5A1, CPT1A, GPR119 | PDK1 343/4885PDK2 346/4885PDK3 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.