Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019741 | 0.88 | CRACR2A (0.38) | TP53RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL987243 | 0.85 | IL2 (0.43) | TP53RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL17375135 | 0.83 | GRM5 (0.38) | RAB9ASMN1; SMN2KMT2AKDM4ENPC1 | |
| SCHEMBL5019609 | 0.83 | AVPR2 (0.42) | TP53RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5019638 | 0.83 | KMT2A (0.41) | TP53RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL5019598 | 0.83 | IL2 (0.40) | RAB9AKMT2AMEN1KDM4ENPC1 | |
| SCHEMBL1781817 | 0.83 | KMT2A (0.50) | TP53RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5019753 | 0.82 | IL2 (0.39) | RAB9ASMN1; SMN2KMT2AALDH1A1KDM4E | |
| SCHEMBL5019637 | 0.82 | KMT2A (0.41) | TP53RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5005018 | 0.80 | IL2 (0.41) | TP53RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |