Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019605 | 0.85 | L3MBTL1 (0.35) | HPGDPTPN11GRM5KDM4EKDR | |
| SCHEMBL5019765 | 0.83 | CSNK1D (0.37) | HPGDPTPN11GRM5KDRSMN1; SMN2 | |
| SCHEMBL5019717 | 0.83 | CRACR2A (0.39) | HPGDKDM4EUSP2 | |
| SCHEMBL5019742 | 0.82 | MAPT (0.39) | PTPN11KDM4ESMN1; SMN2POLBMAPT | |
| SCHEMBL4561084 | 0.82 | WDR5 (0.40) | HPGDKDM4ESMN1; SMN2TP53POLB | |
| SCHEMBL986115 | 0.81 | LRRK2 (0.34) | HPGDNTRK1KDM4EKDRSMN1; SMN2 | |
| SCHEMBL986981 | 0.80 | TRPV1 (0.44) | HPGDNTRK1KDRMTORRAF1 | |
| SCHEMBL4561040 | 0.80 | KMT2A (0.35) | PTPN11GRM5MAPT | |
| SCHEMBL1781495 | 0.80 | RAB9A (0.38) | HPGDPTPN11TP53MAPT | |
| SCHEMBL986998 | 0.80 | STIM1 (0.42) | PTPN11GRM5ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |