Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019762 | 0.80 | HTR1F (0.42) | HTR1FABCB1F10PIK3C3ALDH1A1 | |
| SCHEMBL5019755 | 0.77 | IL2 (0.40) | HTR1FNPC1RAB9ANPY5RF10 | |
| SCHEMBL14093257 | 0.72 | NPC1 (0.45) | HTR1FNPC1RAB9AMAPTKCNH2 | |
| Hydrochloric Acid SCHEMBL3827116 | 0.71 | NPC1 (0.44) | HTR1FNPC1RAB9AMAPTKCNH2 | |
| SCHEMBL3823169 | 0.69 | HTR1F (0.44) | HTR1FABCB1NPC1RAB9AMAPT | |
| SCHEMBL14093241 | 0.68 | HTR1F (0.41) | HTR1FABCB1NPC1RAB9AMAPT | |
| SCHEMBL5019620 | 0.67 | IL2 (0.41) | NPC1RAB9A | |
| SCHEMBL3827811 | 0.66 | HTR1F (0.42) | HTR1FABCB1NPC1RAB9AMAPT | |
| SCHEMBL16472102 | 0.66 | HTR1F (0.44) | HTR1FABCB1NPC1RAB9AMAPT | |
| SCHEMBL7918498 | 0.65 | NTRK1 (0.45) | HTR1FABCB1NPC1RAB9ADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |