Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823169 | 0.90 | HTR1F (0.44) | HTR1FMAP3K5CSNK1DCSNK1EGRM5 | |
| SCHEMBL10819914 | 0.84 | NPC1 (0.40) | HTR1FMAP3K5GRM5ALDH1A1ABCB1 | |
| SCHEMBL5019711 | 0.81 | GRM5 (0.40) | GRM5ABCB1GSK3BDYRK1AF10 | |
| SCHEMBL3827961 | 0.81 | HTR1F (0.42) | HTR1FMAP3K5CSNK1DCSNK1EALDH1A1 | |
| SCHEMBL3823860 | 0.80 | NPC1 (0.48) | HTR1FMAP3K5CSNK1DCSNK1EGRM5 | |
| SCHEMBL5019721 | 0.80 | HTR1F (0.38) | HTR1FALDH1A1ABCB1F10TP53 | |
| SCHEMBL5019752 | 0.79 | HTR1F (0.40) | HTR1FMAP3K5CSNK1DCSNK1EALDH1A1 | |
| SCHEMBL5019599 | 0.77 | SMN1; SMN2 (0.40) | HTR1FMAP3K5GRM5ALDH1A1WNT1 | |
| SCHEMBL12848849 | 0.77 | HTR1F (0.40) | HTR1FMAP3K5CSNK1DCSNK1EALDH1A1 | |
| SCHEMBL5005018 | 0.76 | IL2 (0.41) | HTR1FGRM5ALDH1A1WNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064808-A1 | TETRAZOLYL - TETRAHYDROPYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE - RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-18 | — | — | WO | disclosed |