Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15227112 | 0.88 | KDM1A (0.46) | HTR6HTR2CHTR2AHTR7HTR1A | |
| SCHEMBL5019958 | 0.79 | HTR1A (0.54) | HTR6HTR2CHTR2AHTR1ASLC6A2 | |
| SCHEMBL5020019 | 0.78 | HTR6 (0.54) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL6684030 | 0.78 | HTR2C (0.46) | HTR6HTR2CHTR2AHTR7HTR1A | |
| SCHEMBL5019997 | 0.78 | HTR1A (0.47) | HTR6HTR2CHTR2AHTR1ASLC6A2 | |
| SCHEMBL1162025 | 0.74 | HTR6 (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL15236731 | 0.74 | HTR2C (0.53) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL31640013 | 0.71 | HTR6 (0.52) | HTR6HTR2CPRMT5SIGMAR1CCNT1 | |
| SCHEMBL4672600 | 0.70 | PRMT5 (0.64) | HTR6HTR2CSLC6A2SLC6A3PRMT5 | |
| SCHEMBL5020009 | 0.69 | HTR1A (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062752-A1 | RADIOLABELLED mGLuR2 PET LIGANDS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |