Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15236731 | 0.82 | HTR2C (0.53) | HTR2CHTR6SIGMAR1PRMT5HTR1A | |
| SCHEMBL5020019 | 0.78 | HTR6 (0.54) | HTR2CHTR6SIGMAR1PRMT5HTR1A | |
| SCHEMBL5020041 | 0.78 | HTR6 (0.42) | HTR2CHTR6SIGMAR1PRMT5HTR2A | |
| SCHEMBL25081934 | 0.75 | MAPT (0.64) | HTR1AMAPTMAPK1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL29923085 | 0.74 | PRMT5 (0.62) | HTR2CHTR6SIGMAR1PRMT5SLC6A2 | |
| SCHEMBL31640013 | 0.73 | HTR6 (0.52) | HTR2CHTR6SIGMAR1PRMT5CCNT1 | |
| Hydrochloric Acid SCHEMBL1876817 | 0.73 | MAOB (0.49) | HTR2CHTR6SIGMAR1PRMT5 | |
| SCHEMBL4672600 | 0.72 | PRMT5 (0.64) | HTR2CHTR6SIGMAR1PRMT5SLC6A2 | |
| SCHEMBL15227112 | 0.72 | KDM1A (0.46) | HTR2CHTR6SIGMAR1PRMT5HTR2A | |
| SCHEMBL5020009 | 0.72 | HTR1A (0.51) | HTR2CHTR6SIGMAR1PRMT5HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004006923-A1 | ARYL PIPERIDINE DERIVATIVES AS INDUCERS OF LDL-RECEPTOR EXPRESSION FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |