SCHEMBL5020167

SCHEMBL5020167

Bc1c(C(=O)C(F)(F)F)ccc2nc(C(=O)C(C)C)ccc12

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PLA2G2D Q9UNK4 1/20 0.32
MLYCD O95822 2/20 0.31
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8778506 0.85 PLA2G2D (0.32) PLA2G2DMLYCDHTT
SCHEMBL5020176 0.77 RXFP1 (0.37) HTT
SCHEMBL5020169 0.74 MALT1 (0.34) PLA2G2DMLYCD
SCHEMBL8745732 0.71 NOTUM (0.36)
SCHEMBL8745767 0.67 ALDH1A1 (0.35) HTT
SCHEMBL14747560 0.66 PTPN1 (0.36)
SCHEMBL14747554 0.64 PPARA (0.33) HTT
SCHEMBL10136676 0.62 MGAM (0.61)
SCHEMBL15294421 0.61 HSD17B14 (0.51)
SCHEMBL9946926 0.61 CYP17A1 (0.52)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012064943-A2 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS, INC. (US) 2012-05-18 WO disclosed