SCHEMBL5020306

SCHEMBL5020306

C=CC(=C)N(c1ccc(C)cc1)c1ccc(-c2ccc(Br)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C19 P33261 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 1/20 0.34
LSS P48449 2/20 0.33
MAPK1 P28482 1/20 0.31
TSHR P16473 1/20 0.31
TGM2 P21980 2/20 0.31
F13A1 P00488 1/20 0.31
LMNA P02545 1/20 0.31
TGM1 P22735 1/20 0.31
TGM3 Q08188 1/20 0.31
MMP9 P14780 2/20 0.31
APP P05067 2/20 0.31
MAOB P27338 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20005325 0.74 NPSR1 (0.39) ALDH1A1MEN1CYP3A4HTTKMT2A
SCHEMBL31587506 0.73 EGLN1 (0.34) ALDH1A1HTTLSS
SCHEMBL3446113 0.73 ALDH1A1 (0.59) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL346046 0.73 ALDH1A1 (0.59) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL1960043 0.73 ALDH1A1 (0.59) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL260551 0.72 ALDH1A1 (0.81) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL20664736 0.72 ALDH1A1 (0.36) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL23097206 0.71 ALDH1A1 (0.35) ALDH1A1MEN1KMT2AMAPK1LMNA
SCHEMBL12694224 0.70 ALDH1A1 (0.41) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19
SCHEMBL2486041 0.68 ALDH1A1 (0.52) ALDH1A1MEN1CYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012064987-A1 HYBRID COMPOSITE EMISSIVE CONSTRUCT AND LIGHT-EMITTING DEVICES USING THE SAME NITTO DENKO CORPORATION (JP) 2012-05-18 WO disclosed