Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.48 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21471527 | 0.85 | GSTP1 (0.51) | P2RX3GSTP1GSTM2TGFBR1MEN1 | |
| SCHEMBL23500769 | 0.85 | MEN1 (0.54) | P2RX3GSTP1GSTM2TGFBR1MEN1 | |
| SCHEMBL28409562 | 0.85 | GSTP1 (0.51) | P2RX3GSTP1GSTM2TGFBR1MEN1 | |
| SCHEMBL4082004 | 0.83 | GSTP1 (0.49) | P2RX3GSTP1GSTM2TGFBR1MEN1 | |
| SCHEMBL23500569 | 0.83 | ALDH1A1 (0.51) | P2RX3GSTP1GSTM2MEN1KMT2A | |
| SCHEMBL4819507 | 0.82 | TRPM8 (0.41) | P2RX3TGFBR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL38654486 | 0.82 | TRPM8 (0.41) | P2RX3TGFBR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1350794 | 0.82 | GSTP1 (0.48) | P2RX3GSTP1GSTM2MEN1KMT2A | |
| SCHEMBL25197301 | 0.81 | P2RX3 (0.49) | P2RX3GSTP1GSTM2TGFBR1MEN1 | |
| SCHEMBL5020588 | 0.81 | P2RX3 (0.49) | P2RX3GSTP1GSTM2TGFBR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848454-A | Histone deacetylase 6 inhibitor and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848454-B | Histone deacetylase 6 inhibitor and preparation method and application thereof | 山东大学 | 2021-05-07 | — | — | CN | disclosed |
| CN-111848454-A | Histone deacetylase 6 inhibitor and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146623-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | P2RX3 3257/4885GSTP1 1856/4885GSTM2 2939/4885 |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | P2RX3 3257/4885GSTP1 1856/4885GSTM2 2939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.