Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | P4HB | P07237 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5047215 | 0.87 | HDAC1 (1.00) | HDAC1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5020769 | 0.84 | HDAC1 (0.78) | HDAC1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL15238912 | 0.83 | MEN1 (0.69) | MEN1KMT2ATDP1MAPT | |
| SCHEMBL811912 | 0.83 | MEN1 (0.69) | MEN1KMT2ATDP1MAPT | |
| SCHEMBL279483 | 0.83 | MEN1 (0.69) | MEN1KMT2ATDP1MAPT | |
| SCHEMBL5020756 | 0.83 | HDAC1 (0.76) | HDAC1CA2CA1HDAC4HDAC8 | |
| SCHEMBL5020762 | 0.83 | HDAC1 (0.76) | HDAC1MEN1KMT2AKDM4EHDAC4 | |
| SCHEMBL3484305 | 0.82 | HDAC1 (0.69) | HDAC1P4HB | |
| SCHEMBL3484304 | 0.82 | HDAC1 (0.69) | HDAC1P4HB | |
| SCHEMBL5020765 | 0.81 | HDAC1 (0.79) | HDAC1MEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |