Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.54 |
| ▸ | NAMPT | P43490 | 4/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020623 | 0.88 | HDAC1 (0.72) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL14629692 | 0.85 | HDAC1 (0.54) | KEAP1NFE2L2HDAC1HDAC8HDAC4 | |
| SCHEMBL5020766 | 0.79 | HDAC1 (0.80) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5020769 | 0.78 | HDAC1 (0.78) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5020774 | 0.77 | HDAC1 (0.77) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5015931 | 0.77 | KEAP1 (0.68) | KEAP1NFE2L2NAMPTSNCAALDH1A1 | |
| SCHEMBL5020756 | 0.76 | HDAC1 (0.76) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5020762 | 0.76 | HDAC1 (0.76) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL5020746 | 0.76 | HDAC1 (0.49) | HDAC1HDAC8HDAC4HDAC3HDAC7 | |
| SCHEMBL10031599 | 0.76 | SNCA (0.59) | KEAP1NFE2L2NAMPTSNCAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |