Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048456 | 0.87 | HDAC1 (0.66) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL5020749 | 0.77 | HDAC1 (0.80) | HDAC1MEN1KMT2AMAPTHTT | |
| SCHEMBL5012450 | 0.76 | ALDH1A1 (0.60) | MEN1KMT2AKDM4EHTTMETAP2 | |
| SCHEMBL5020754 | 0.76 | KEAP1 (0.55) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL8164647 | 0.75 | GLO1 (0.55) | MEN1KMT2AKDM4EMETAP2 | |
| SCHEMBL5020774 | 0.75 | HDAC1 (0.77) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL5332392 | 0.75 | TSHR (0.52) | MEN1KMT2AMAPTHTTMETAP2 | |
| SCHEMBL5020747 | 0.73 | HDAC1 (0.78) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL5020753 | 0.73 | HDAC1 (0.78) | HDAC1HDAC4HDAC8HDAC3HDAC7 | |
| SCHEMBL29184120 | 0.73 | KDM4E (0.58) | MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |