Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021831 | 0.85 | POLB (0.47) | KDM4EGAAPOLBALDH1A1LMNA | |
| SCHEMBL19397817 | 0.85 | ALDH1A1 (0.57) | KDM4EGAAPOLBALDH1A1LMNA | |
| SCHEMBL2696947 | 0.80 | GAA (0.51) | KDM4EGAAPOLBLMNAKMT2A | |
| SCHEMBL28113666 | 0.78 | ALDH1A1 (0.56) | KDM4EGAAALDH1A1LMNAL3MBTL1 | |
| SCHEMBL10823675 | 0.78 | MGLL (0.56) | ALDH1A1LMNAL3MBTL1SMN1; SMN2MGLL | |
| SCHEMBL14933444 | 0.77 | ALDH1A1 (0.55) | KDM4EGAAALDH1A1LMNAL3MBTL1 | |
| SCHEMBL12910285 | 0.77 | POLB (1.00) | KDM4EGAAPOLBALDH1A1KMT2A | |
| SCHEMBL28274744 | 0.73 | ALDH1A1 (0.51) | KDM4EGAAALDH1A1LMNAL3MBTL1 | |
| SCHEMBL22203819 | 0.73 | TDP1 (0.68) | KDM4EGAAPOLBALDH1A1LMNA | |
| Methaqualone SCHEMBL20471677 | 0.73 | ALDH1A1 (1.00) | GAAPOLBALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403859-B1 | MOLECULAR TWEEZERS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | UNIV CALIFORNIA (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2403859-B1 | MOLECULAR TWEEZERS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | UNIV CALIFORNIA (US) | 2017-05-03 | — | — | EP | disclosed |
| US-8791092-B2 | Molecular tweezers for the treatment of amyloid-related diseases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-29 | — | — | US | disclosed |
| US-8791092-B2 | Molecular tweezers for the treatment of amyloid-related diseases | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-29 | — | — | US | disclosed |
| US-20120108548-A1 | MOLECULAR TWEEZERS FOR THE TREATMENT OF AMYLOID-RELATED DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108548-A1 | MOLECULAR TWEEZERS FOR THE TREATMENT OF AMYLOID-RELATED DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108548-A1 | MOLECULAR TWEEZERS FOR THE TREATMENT OF AMYLOID-RELATED DISEASES | APP, PSEN1, PSEN2 | KDM4E 264/4885GAA 2027/4885POLB 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.