Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18077984 | 1.00 | ACHE (0.44) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL22288271 | 0.83 | HDAC4 (0.37) | HDAC4 | |
| SCHEMBL179253 | 0.81 | ACHE (0.48) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL792296 | 0.81 | ACHE (0.48) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL23343758 | 0.79 | PGK1 (0.39) | HDAC4 | |
| Ammonia Solution, Strong SCHEMBL6000669 | 0.79 | ACHE (0.46) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL17591473 | 0.79 | ACHE (0.46) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL18372950 | 0.78 | HDAC4 (0.46) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL4702366 | 0.78 | HDAC4 (0.48) | ACHEHDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL17069219 | 0.77 | AOC3 (0.46) | ACHEHDAC4HDAC7HDAC5IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638014-B1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF ROR-GAMMA ACTIVITY AND THE TREATMENT OF DISEASES | LYCERA CORP (US) | 2017-01-04 | — | — | EP | disclosed |
| WO-2012064744-A2 | TETRAHYDROQUINOLINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORϒ ACTIVITY AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |