SCHEMBL22288271

SCHEMBL22288271

CC(I)c1cccc(C(C)I)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 3/20 0.37
HDAC8 Q9BY41 3/20 0.37
MAPT P10636 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 2/20 0.37
HPGD P15428 2/20 0.37
HDAC2 Q92769 2/20 0.37
MDM4 O15151 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
TP53 P04637 1/20 0.37
TYR P14679 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
CA5A P35218 1/20 0.37
HTT P42858 1/20 0.37
MDM2 Q00987 1/20 0.37
CA9 Q16790 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19424129 0.92 HDAC4 (0.47) HDAC4HDAC8MAPTSMN1; SMN2KDM4E
SCHEMBL23343758 0.90 PGK1 (0.39) HDAC4HDAC8MAPTSMN1; SMN2KDM4E
SCHEMBL5022111 0.85 ACHE (0.50) MAPTALDH1A1CYP3A4HPGDTP53
SCHEMBL7329842 0.85 ACHE (0.50) MAPTALDH1A1CYP3A4HPGDTP53
SCHEMBL5022113 0.83 ACHE (0.44) HDAC4
SCHEMBL13069683 0.83 CYP3A4 (0.48) MAPTKDM4EALDH1A1CYP3A4CA1
SCHEMBL23343875 0.83 ADRB1 (0.57) KDM4EALDH1A1CYP3A4CA2TYR
SCHEMBL20057647 0.83 CYP3A4 (0.48) MAPTKDM4EALDH1A1CYP3A4CA1
SCHEMBL7329286 0.83 ALDH1A1 (0.44) SMN1; SMN2ALDH1A1CYP3A4MEN1KMT2A
SCHEMBL18077984 0.83 ACHE (0.44) HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110002930-B Method for hydrogenation reduction of alkenyl aromatic halogenated derivatives 浙江大学 2020-05-12 CN claimed
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
CN-111517902-B Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2022-06-14 CN disclosed
CN-111517902-A Aerobic oxidation system containing sulfinic acid, sulfonic acid or derivatives thereof and photo-oxidation promoting method thereof 清华大学 2020-08-11 CN disclosed
WO-2020155595-A1 AEROBIC OXIDATION SYSTEM CONTAINING SULFINIC ACID, SULFONIC ACID OR DERIVATIVES THEREOF AND PHOTOCATALYTIC OXIDATION METHOD THEREFOR 清华大学 2020-08-06 WO disclosed
CN-110002930-B Method for hydrogenation reduction of alkenyl aromatic halogenated derivatives 浙江大学 2020-05-12 CN disclosed