Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5051495 | 0.88 | KDM4E (0.49) | MRGPRX1SMN1; SMN2L3MBTL1PTPN1PKM | |
| SCHEMBL1188345 | 0.85 | TSHR (0.56) | MRGPRX1L3MBTL1TSPOHCRTR1PKM | |
| SCHEMBL31078354 | 0.85 | TSHR (0.56) | MRGPRX1L3MBTL1TSPOHCRTR1PKM | |
| SCHEMBL2097494 | 0.84 | HPGDS (0.54) | SMN1; SMN2PTPN1PKMKDM4EHPGDS | |
| SCHEMBL29586157 | 0.84 | HPGDS (0.54) | SMN1; SMN2PTPN1PKMKDM4EHPGDS | |
| SCHEMBL11755786 | 0.83 | KDM4E (0.58) | ALDH1A1L3MBTL1HCRTR1KDM4EHPGDS | |
| SCHEMBL3165420 | 0.82 | CYP3A4 (0.61) | MRGPRX1ALDH1A1SMN1; SMN2L3MBTL1TSPO | |
| SCHEMBL30628345 | 0.82 | CYP3A4 (0.61) | MRGPRX1ALDH1A1SMN1; SMN2L3MBTL1TSPO | |
| SCHEMBL14364673 | 0.82 | MRGPRX1 (0.45) | MRGPRX1ALDH1A1SMN1; SMN2L3MBTL1TSPO | |
| SCHEMBL11287767 | 0.81 | MRGPRX1 (0.49) | MRGPRX1ALDH1A1SMN1; SMN2L3MBTL1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| EP-1894917-A1 | Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer | Basilea Pharmaceutica AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1894917-A1 | Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer | Basilea Pharmaceutica AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1697336-B1 | AROYLFURANES AND AROYLTHIOPHENES SUITABLE FOR THE TREATMENT OF CANCER | BASILEA PHARMACEUTICA AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| US-20060205739-A1 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG | 2006-09-14 | — | — | US | disclosed |
| EP-1697336-A2 | AROYLFURANES AND AROYLTHIOPHENES SUITABLE FOR THE TREATMENT OF CANCER | Basilea Pharmaceutica AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061476-A2 | AROYLFURANES AND AROYLTHIOPHENES | BASILEA PHARMACEUTICA AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205739-A1 | Aroylfuranes and aroylthiophenes | TPMT, APRT, ABAT | MRGPRX1 1925/4885ALDH1A1 308/4885SMN1; SMN2 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.