SCHEMBL5023563

SCHEMBL5023563

COC(=O)c1sc2cc(C)ccc2c1Cl

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 2/20 0.70
BCL2L1 Q07817 1/20 0.70
RAB9A P51151 9/20 0.64
MAPT P10636 9/20 0.64
NPC1 O15118 8/20 0.64
LMNA P02545 3/20 0.64
GAA P10253 2/20 0.64
SMN1; SMN2 Q16637 7/20 0.56
NPSR1 Q6W5P4 3/20 0.56
PPARG P37231 2/20 0.56
NR2E3 Q9Y5X4 1/20 0.56
NCOR2 Q9Y618 1/20 0.56
PKM P14618 1/20 0.54
RXFP1 Q9HBX9 3/20 0.54
PRNP P04156 1/20 0.54
TSHR P16473 1/20 0.54
MAPK1 P28482 1/20 0.54
HTT P42858 1/20 0.54
MAPK10 P53779 1/20 0.54
NCOA2 Q15596 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15471997 0.89 BCL2L1 (0.55) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL8010663 0.85 BCL2L1 (0.67) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL8412494 0.85 NPSR1 (0.74) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL15619431 0.84 BCL2L1 (0.53) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL12501358 0.84 MAPK1 (0.56) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL693146 0.84 BCKDK (0.68) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL13926048 0.83 BCL2L1 (0.51) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL2431312 0.83 MAPT (0.52) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL12325629 0.83 MAPT (0.55) MCL1BCL2L1RAB9AMAPTNPC1
SCHEMBL12325628 0.83 MAPT (0.52) MCL1BCL2L1RAB9AMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750728-A TREATING AROMATIC METHYL COMPOUND DISSOLVED IN CHLOROBENZENE WITH N-BROMOSUCCINIMIDE CLARIANT GMBH (DE) 1998-05-12 US claimed
US-8431684-B2 Process for the preparation of ibodutant (MEN15596) and related intermediates MALESCI ISTITUTO FARMACOBIOLOGICO S.P.A. (IT) 2013-04-30 US disclosed
WO-2011109679-A2 INHIBITORS OF 5-LIPOXYGENASE AMIRA PHARMACEUTICALS, INC. (US) 2011-09-09 WO disclosed
EP-1915369-A1 NOVEL SUBSTITUTED 1,2,3-T II AZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTIIENE BIOSYNTHESIS INHIBITORS Merck Frosst Canada Ltd. (CA) 2008-04-30 EP disclosed
WO-2007016784-A1 NOVEL SUBSTITUTED 1,2,3-TΠAZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTΠENE BIOSYNTHESIS INHIBITORS MERCK FROSST CANADA LTD. (CA) 2007-02-15 WO disclosed
WO-2007016784-A1 NOVEL SUBSTITUTED 1,2,3-TΠAZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTΠENE BIOSYNTHESIS INHIBITORS MERCK FROSST CANADA LTD. (CA) 2007-02-15 WO disclosed
EP-0533058-B1 Imidazo-fused iso- and heterocycles as angiotensin II antagonists HOECHST AG (DE) 2003-08-20 EP disclosed
US-5863936-A HETEROCYCLIC ENZYME INHIBITORS AS ANTICANCER AGENTS GERON CORPORATION (US) 1999-01-26 US disclosed
US-5760062-A ANTICANCER AGENTS GERON CORPORATION (US) 1998-06-02 US disclosed
US-5750728-A TREATING AROMATIC METHYL COMPOUND DISSOLVED IN CHLOROBENZENE WITH N-BROMOSUCCINIMIDE CLARIANT GMBH (DE) 1998-05-12 US disclosed
US-5703116-A TREATING CANCER GERON CORPORATION (US) 1997-12-30 US disclosed
US-5635525-A DIAGNOSTICS HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-03 US disclosed
US-5444068-A Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith HOECHST AKTIENGESELLSCHAFT (DE) 1995-08-22 US disclosed
EP-0533058-A1 Imidazo-fused iso- and heterocycles as angiotensin II antagonists HOECHST AKTIENGESELLSCHAFT (DE) 1993-03-24 EP disclosed