Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020988 | 0.87 | CYP4F2 (0.54) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL12325629 | 0.86 | MAPT (0.55) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL12325628 | 0.86 | MAPT (0.52) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL8323119 | 0.83 | MCL1 (0.66) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL5023563 | 0.83 | MCL1 (0.70) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL14614991 | 0.81 | MAPT (0.49) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL8412494 | 0.80 | NPSR1 (0.74) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL9045796 | 0.79 | MAPT (0.42) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL693146 | 0.79 | BCKDK (0.68) | MAPTLMNAGAAALDH1A1KDM4E | |
| SCHEMBL12501358 | 0.79 | MAPK1 (0.56) | MAPTLMNAGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750728-A | TREATING AROMATIC METHYL COMPOUND DISSOLVED IN CHLOROBENZENE WITH N-BROMOSUCCINIMIDE | CLARIANT GMBH (DE) | 1998-05-12 | — | — | US | claimed |
| WO-2011109679-A2 | INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| WO-2011109679-A2 | INHIBITORS OF 5-LIPOXYGENASE | AMIRA PHARMACEUTICALS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| EP-1915369-A1 | NOVEL SUBSTITUTED 1,2,3-T II AZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTIIENE BIOSYNTHESIS INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007016784-A1 | NOVEL SUBSTITUTED 1,2,3-TΠAZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTΠENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007016784-A1 | NOVEL SUBSTITUTED 1,2,3-TΠAZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTΠENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-02-15 | — | — | WO | disclosed |
| EP-0533058-B1 | Imidazo-fused iso- and heterocycles as angiotensin II antagonists | HOECHST AG (DE) | 2003-08-20 | — | — | EP | disclosed |
| US-5750728-A | TREATING AROMATIC METHYL COMPOUND DISSOLVED IN CHLOROBENZENE WITH N-BROMOSUCCINIMIDE | CLARIANT GMBH (DE) | 1998-05-12 | — | — | US | disclosed |
| US-5635525-A | DIAGNOSTICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-03 | — | — | US | disclosed |
| US-5444068-A | Imidazopyridine derivatives as angiotensin II receptor antagonists, pharmaceuticals, and treatment of hypertension therewith | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-08-22 | — | — | US | disclosed |
| EP-0533058-A1 | Imidazo-fused iso- and heterocycles as angiotensin II antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |