Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017849 | 0.75 | SETD7 (0.44) | HPGDALDH1A1TOP2ACHEK1TLR9 | |
| SCHEMBL4289142 | 0.75 | CHEK1 (0.71) | HPGDKDM4EALDH1A1HSD17B10TOP2A | |
| SCHEMBL5024319 | 0.74 | CD274 (0.42) | HPGD | |
| SCHEMBL5017565 | 0.73 | METAP2 (0.49) | HPGDKDM4EALDH1A1HSD17B10TOP2A | |
| SCHEMBL5017853 | 0.68 | METAP2 (0.43) | MAPK14PARP1 | |
| SCHEMBL10020214 | 0.64 | HPGD (0.79) | HPGDKDM4EALDH1A1HSD17B10NPC1 | |
| SCHEMBL5017106 | 0.63 | CHEK1 (0.50) | CHEK1 | |
| SCHEMBL15382631 | 0.63 | SIGMAR1 (0.69) | HPGDKDM4EALDH1A1HSD17B10EGLN1 | |
| SCHEMBL7556161 | 0.62 | NAMPT (0.58) | HPGDKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL24553422 | 0.62 | MAPK14 (0.61) | HPGDKDM4EALDH1A1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |