Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017849 | 0.80 | SETD7 (0.44) | HPGD | |
| SCHEMBL4290123 | 0.78 | CHEK1 (0.55) | CD274HPGDMTORHPGDS | |
| SCHEMBL5024099 | 0.74 | HPGD (0.41) | HPGD | |
| SCHEMBL5017565 | 0.74 | METAP2 (0.49) | HPGD | |
| SCHEMBL5017853 | 0.69 | METAP2 (0.43) | — | |
| SCHEMBL5025837 | 0.67 | JAK2 (0.48) | HPGD | |
| SCHEMBL28576222 | 0.63 | MAPK14 (0.55) | — | |
| SCHEMBL10020214 | 0.63 | HPGD (0.79) | HPGD | |
| SCHEMBL24061013 | 0.62 | HPGD (0.65) | HPGD | |
| SCHEMBL5015640 | 0.62 | ERN1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | claimed |
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |