Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.48 |
| ▸ | ERN1 | O75460 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015640 | 0.82 | ERN1 (0.45) | JAK2ERN1ALDH1A1 | |
| SCHEMBL5024158 | 0.81 | TP53 (0.41) | — | |
| SCHEMBL5017431 | 0.80 | EPRS1 (0.43) | — | |
| SCHEMBL5017584 | 0.77 | NOS3 (0.35) | CHEK1HRH3 | |
| SCHEMBL5025821 | 0.76 | NR4A2 (0.35) | ERN1CHEK1ALDH1A1 | |
| SCHEMBL5025819 | 0.73 | DHODH (0.46) | ERN1 | |
| SCHEMBL4290168 | 0.72 | CHEK1 (0.49) | JAK2ERN1CHEK1CSF1RHPGD | |
| SCHEMBL5025775 | 0.70 | HSD17B1 (0.45) | CHEK1ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL4248924 | 0.68 | HPGD (0.73) | JAK2ERN1HPGDALDH1A1MEN1 | |
| SCHEMBL5017045 | 0.68 | TP53 (0.44) | HPGDALDH1A1MEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | claimed |