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SCHEMBL5024381

SCHEMBL5024381

CC1CN(C(=O)O)CC(C)N1CC(O)Cn1c2ccccc2c2cc(Cl)ccc21

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ RAD52 P43351 1/20 0.47
▸ NLRP1 Q9C000 1/20 0.47
▸ PER2 O15055 11/20 0.47
▸ ALDH1A1 P00352 1/20 0.45
▸ LMNA P02545 1/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ BACE1 P56817 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL609875 0.87 CNR2 (0.45) RAD52NLRP1PER2ALDH1A1LMNA
SCHEMBL609624 0.83 RAD52 (0.51) RAD52NLRP1PER2ALDH1A1LMNA
SCHEMBL5028634 0.81 RAD52 (0.41) RAD52NLRP1PER2ALDH1A1LMNA
SCHEMBL606776 0.77 RAD52 (0.57) RAD52NLRP1PER2ALDH1A1LMNA
SCHEMBL6816191 0.75 RAD52 (0.76) RAD52NLRP1ALDH1A1LMNAMEN1
SCHEMBL6819364 0.75 RAD52 (0.76) RAD52NLRP1ALDH1A1LMNAMEN1
SCHEMBL5087921 0.74 RAD52 (0.70) RAD52NLRP1ALDH1A1LMNAMEN1
SCHEMBL16604024 0.73 RAD52 (0.74) RAD52NLRP1ALDH1A1LMNAMEN1
SCHEMBL1306615 0.73 MEN1 (0.70) RAD52NLRP1ALDH1A1LMNAMEN1
SCHEMBL607619 0.72 LMNA (0.81) RAD52NLRP1ALDH1A1LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1237887-B1 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS SERONO LAB (CH) 2008-06-04 — — EP claimed