Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | BAX | Q07812 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607343 | 0.84 | BAX (0.61) | MAPTTP53MAPK1HTTRAD52 | |
| SCHEMBL607520 | 0.78 | TACR1 (0.50) | MAPTTP53MAPK1HTTATM | |
| SCHEMBL607341 | 0.76 | RAD52 (0.76) | MAPTTP53MAPK1HTTRAD52 | |
| SCHEMBL5022789 | 0.73 | BAX (0.51) | MAPTTP53MAPK1RAD52BAX | |
| SCHEMBL30733932 | 0.72 | CHRM5 (0.53) | — | |
| SCHEMBL9322314 | 0.71 | KDM4E (0.49) | MAPTTP53HTTATMCYP3A4 | |
| SCHEMBL4877367 | 0.69 | KMT2A (0.53) | MAPTMAPK1KDM4EALDH1A1 | |
| SCHEMBL27520426 | 0.67 | KDM4E (0.72) | MAPTKDM4ETSHRALOX12L3MBTL1 | |
| SCHEMBL8861848 | 0.67 | ATM (0.46) | MAPTTP53HTTATMCYP3A4 | |
| SCHEMBL5026836 | 0.67 | KRAS (0.46) | MAPTTP53MAPK1RAD52BAX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |