Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22866307 | 0.79 | ALDH1A1 (0.59) | BCL6L3MBTL1ALDH1A1TLR7STK17A | |
| SCHEMBL179459 | 0.79 | PTPN1 (0.48) | L3MBTL1APPTLR8NUDT1ALDH1A1 | |
| SCHEMBL26944952 | 0.77 | L3MBTL1 (0.46) | L3MBTL1APPTLR8NUDT1ALDH1A1 | |
| SCHEMBL18855177 | 0.77 | BCL6 (0.50) | BCL6L3MBTL1TLR8NUDT1 | |
| SCHEMBL2744648 | 0.76 | BCL6 (0.56) | BCL6L3MBTL1NUDT1ALDH1A1STK17A | |
| SCHEMBL217587 | 0.75 | BCL6 (0.47) | BCL6L3MBTL1TLR8NUDT1TLR7 | |
| SCHEMBL9925932 | 0.73 | BCL6 (0.46) | BCL6L3MBTL1TLR8NUDT1ALDH1A1 | |
| SCHEMBL9925942 | 0.73 | BCL6 (0.46) | BCL6L3MBTL1TLR8NUDT1ALDH1A1 | |
| SCHEMBL218364 | 0.73 | BCL6 (0.46) | BCL6L3MBTL1TLR8NUDT1ALDH1A1 | |
| SCHEMBL4480627 | 0.73 | LMNA (0.43) | BCL6L3MBTL1NUDT1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | claimed |