Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29194955 | 0.81 | ABL1 (0.42) | NR1H2NR1H3LOXL2BRD4CREBBP | |
| SCHEMBL730864 | 0.77 | CYP1A1 (0.45) | CYP2C9LMNA | |
| SCHEMBL6525290 | 0.77 | ADRB2 (0.41) | PTPRC | |
| SCHEMBL17165959 | 0.74 | FAAH (0.42) | NR1H2NR1H3LOXL2CTSSCTSK | |
| SCHEMBL20360670 | 0.73 | FAAH (0.48) | NR1H2NR1H3PTGDR2LOXL2BRD4 | |
| SCHEMBL7650568 | 0.71 | KCNH2 (0.42) | NR1H2NR1H3LOXL2CTSSCTSK | |
| SCHEMBL145847 | 0.71 | NR1H2 (0.45) | NR1H2NR1H3LOXL2CTSSCTSK | |
| SCHEMBL29196085 | 0.70 | ALDH1A1 (0.44) | PTPRC | |
| SCHEMBL8088891 | 0.69 | ALDH1A1 (0.35) | PTPRCPTGDR2LMNAPOLB | |
| SCHEMBL6243674 | 0.68 | KCNH2 (0.50) | NR1H2NR1H3LOXL2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | claimed |