Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174676 | 0.81 | GRM5 (0.76) | GRM5 | |
| SCHEMBL28326270 | 0.80 | GRM5 (0.76) | GRM5KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL13296220 | 0.78 | GRM5 (0.82) | GRM5KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL23733271 | 0.78 | GRM5 (0.72) | GRM5MEN1KMT2ASORT1NPC1 | |
| SCHEMBL5029221 | 0.77 | GRM5 (0.70) | GRM5KMT2A | |
| SCHEMBL1795107 | 0.77 | GRM5 (0.70) | GRM5MEN1KMT2ASORT1NPC1 | |
| SCHEMBL9377973 | 0.76 | GRM5 (0.69) | GRM5KMT2ASORT1NPC1RAB9A | |
| SCHEMBL9963860 | 0.76 | GRM5 (0.75) | GRM5NPC1RAB9A | |
| SCHEMBL9753586 | 0.75 | RAB9A (0.88) | GRM5MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8557860 | 0.75 | GRM5 (1.00) | GRM5SORT1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092072-A2 | MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 AND USES THEREOF | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-07-31 | — | — | WO | disclosed |