Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030205 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1RAB9AMAPTGAA | |
| SCHEMBL5028936 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1RAB9AMAPTGAA | |
| SCHEMBL5027035 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1RAB9AGAAKDM4E | |
| SCHEMBL5028973 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1RAB9AGAAKDM4E | |
| SCHEMBL5029243 | 0.72 | — | — | |
| SCHEMBL5033369 | 0.72 | — | — | |
| SCHEMBL4395390 | 0.70 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1RAB9AMAPTGAA | |
| SCHEMBL5027037 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1RAB9AGAAKDM4E | |
| SCHEMBL5029144 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1RAB9AGAAKDM4E | |
| SCHEMBL4397899 | 0.66 | GLA (0.55) | SMN1; SMN2ALDH1A1RAB9AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |