Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027037 | 1.00 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL5027035 | 0.77 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2GAAL3MBTL1HPGD | |
| SCHEMBL5028973 | 0.77 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2GAAL3MBTL1HPGD | |
| SCHEMBL4399822 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL4393320 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL4398585 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL4393412 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL5451660 | 0.70 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL9259868 | 0.69 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2GAALMNAHTT | |
| SCHEMBL12069272 | 0.69 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2GAALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |