Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TAS2R38 | P59533 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027035 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2CYP1A2KMT2AALDH1A1MEN1 | |
| SCHEMBL5027101 | 0.87 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP1A2KMT2AALDH1A1MEN1 | |
| SCHEMBL5030205 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL5027037 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2KMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL5029144 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2KMT2AALDH1A1MEN1RAB9A | |
| SCHEMBL5033369 | 0.73 | — | — | |
| SCHEMBL5029243 | 0.73 | — | — | |
| SCHEMBL8392583 | 0.73 | TAS2R38 (0.52) | SMN1; SMN2KMT2AALDH1A1MEN1RXFP1 | |
| SCHEMBL16526076 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1TAS2R38RAB9ANPC1 | |
| SCHEMBL10951117 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1TAS2R38RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |