Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025845 | 0.96 | CHRNB4 (0.49) | ALDH1A1CYP3A4CHRNB4CHRNA3CHEK2 | |
| SCHEMBL11449248 | 0.91 | CHRNB4 (0.50) | CHRNB4CHRNA3CHEK2MEN1KMT2A | |
| SCHEMBL11457361 | 0.87 | CHRNB4 (0.54) | CHRNB4CHRNA3CHEK2MEN1KMT2A | |
| SCHEMBL11449154 | 0.84 | LTA4H (0.50) | CHEK2CYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL11715221 | 0.82 | LTA4H (0.53) | CHEK2LTA4H | |
| SCHEMBL11449447 | 0.82 | CYP1A2 (0.48) | CHRNB4CHRNA3CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11716280 | 0.81 | LTA4H (0.50) | CHRNB4CHRNA3CHEK2LTA4H | |
| SCHEMBL6073607 | 0.81 | CHRNB4 (0.47) | CHRNB4CHRNA3CHEK2CYP1A2CYP2D6 | |
| SCHEMBL6628961 | 0.81 | CHRNB4 (0.51) | CHRNB4CHRNA3CHEK2CYP1A2CYP2D6 | |
| SCHEMBL6600614 | 0.81 | NFE2L2 (0.60) | CHEK2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919892-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027527-A2 | ISOINDOLE-IMIDE COMPOUNDS AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME | CELGENE CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |